Enid Sabel · @enidsabel
Zepbound week 1 — symptoms and measurements
Published
“−2 lb and some inches still felt like it’s working.”
Chapters
Enid’s video is a true week-one diary: nausea timing, thirst, sleep, tape measure, and shot #2. If you’re about to start — or just started — and want honest granularity instead of a dramatic before/after, sit with her first week.
- Med
- Zepbound (tirzepatide)
- Start weight
- 177.8 lb
- Week 1
- 175.8 lb (−2 lb)
- Care
- Discussed with doctor · ~3-month check-in planned
- Context
- Lymphedema / fluid retention (her note)
Week one starts with numbers
177.8 lb and a full tape-measure baseline before she walks through symptoms.
Symptoms can show up hours later
Fine most of the day after an 11 a.m. shot — evening nausea started around hour ten.
Thirst hit hard early
Intense for the first few days, and it pushed more water in than she usually drinks.
Sleep felt deeper
One of the quieter changes she noticed night after night — hard to separate from cycle fatigue.
−2 lb and inches still felt like progress
Glad it was steady — not a crash — with arm, bust, and waist changes alongside the scale.
Considering
She was still uneasy about “what I’m injecting,” and comfort came from her doctor’s walkthrough plus a planned check-in around three months. She frames the shot as her kickstart — other paths are valid too. You can feel uneasy about injections and still choose to begin with a plan.
Week 1 symptoms
Shot around late morning; she felt okay for hours, then evening nausea and reflux. Days one and two were hardest; hunger dropped but didn’t vanish. Intense thirst early on, deeper sleep, fatigue (her period also started — hard to separate). She skipped workouts week one to see what the med was doing. By midweek, sugar interest crept back and she wondered if the dose was “wearing off.” Shot two felt easier with a simple ritual.
Measurements & next intentions
She was glad for −2 lb plus arm, bust, and waist changes. Looser jeans reinforced the tape. Preferring steady week-one loss over a crash is a valid mindset. She planned more intentional protein, hydration, and a gradual return to workouts.
Questions for a clinician
More on how the first weeks tend to go: First weeks on a GLP-1.
- What should I watch for in week one, and when do I call?
- How do we time doses around my cycle and activity?
- What’s a sensible ramp back into exercise as I adjust?
Also in First months
This story belongs to Enid Sabel. Watch the full video on YouTube